PD-L1/HDAC-IN-1
PD-L1/HDAC-IN-1 (Compound 14) is a dual inhibitor of the PD-1/PD-L1 axis and HDAC2/3, with IC50 values in the nanomolar range. It upregulates PD-L1 and CXCL10 in vitro, promoting T-cell recruitment to the tumor microenvironment for immune-oncology research in both cellular and animal models.
Product Specifications
CAS Number
2923313-69-1
Field of Research
Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation, Immunology & Inflammation; Epigenetics & Chromatin, Molecular Biology
Smiles
C (C1=C (OCC2=CC (C#N) =CC=C2) C=C (OCC3=C (C) C (=CC=C3) C4=CC (OCCCCCCC (NO) =O) =CC=C4) C (Cl) =C1) N5[C@@H] (C (O) =O) CCCC5
Molecular Formula
C42H46ClN3O7
Molecular Weight
740.284
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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