Ontunisertib
Ontunisertib is a potent small molecule inhibitor of TGFβRI/ALK5, demonstrating IC50 values of 100-500 nM for TGFβRI and ≤100 nM for ALK5. It is utilized in research for gastrointestinal diseases, fibrosis, and cancer, with applications in both in vitro cellular assays and in vivo preclinical models.
Product Specifications
CAS Number
2647949-48-0
Field of Research
Stem Cell & Developmental Biology
Smiles
O=C (NCC=1C (F) =CC=CC1F) CN2N=C (C=3N=C (C=CC3) C) C (=C2) C=4C=CN=C5C=CC=CC54
Molecular Formula
C27H21F2N5O
Molecular Weight
469.485
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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