KEAP1-NRF2 PPI-IN-1

KEAP1-NRF2PPI-IN-1 (compound 23) is a small molecule inhibitor that disrupts the KEAP1-NRF2 protein-protein interaction. It demonstrates inhibitory activity with IC50 values of 136 nM in human TK6 cells and 62 nM in insect SF9 cells in DNA damage assays, supporting its use in research on oxidative stress and cytoprotection pathways.