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Antidepressant agent 8

Compound 1f is a selective GluN1/2A NMDA receptor antagonist (IC50 = 2.94 μM) with demonstrated blood-brain barrier permeability. It exhibits antidepressant-like activity in a zebrafish depression model, supporting its utility in neuroscience research for studying NMDA receptor function and depression pathophysiology.

Product Specifications

CAS Number

3066104-04-6

Field of Research

Neuroscience, Pharmacology & Drug Discovery

Smiles

O=C (NCC1CCCCC1) CSC2=NN=C (S2) NCC=3C=CC=C (F) C3

Molecular Formula

C18H23FN4OS2

Molecular Weight

394.53

Storage Conditions

-20°C

Notes

For research use only.

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