CDK12/13-IN-2

CDK12/13-IN-2 is a potent covalent inhibitor of CDK12 (IC50=15.5 nM) and CDK13 (IC50=12.2 nM) . It demonstrates anti-proliferative activity in breast cancer cell lines and serves as a valuable chemical probe for studying transcription regulation and therapeutic strategies in cancers like triple-negative breast cancer.