MSC1094308

MSC1094308 is a non-competitive and reversible VPS4B/p97 (VCP) (I/II type AAA ATPase) allosteric inhibitor, with IC50 values of 0.71 μM and 7.2 μM for VPS4B and p97, respectively[1]. MSC1094308 inhibits the D2 ATPase activity by binding to a agentable hotspot of p97. MSC1094308 can be used in study of cancer[1].

Product Specifications

CAS Number

[2219320-08-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

P97

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/msc1094308.html

Purity

99.89

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

FC1=CC=C(C(C2=CC=C(F)C=C2)CCCNCC3CCC(NC4=C5C=C(F)C=C4)=C5C3)C=C1

Molecular Formula

C29H29F3N2

Molecular Weight

462.55

Precautions

H302, H315, H319, H335

References & Citations

[1]Pöhler R, et al. A Non-Competitive Inhibitor of VCP/p97 and VPS4 Reveals Conserved Allosteric Circuits in Type I and II AAA ATPases. Angew Chem Int Ed Engl. 2018 Feb 5;57 (6) :1576-1580.