E3 ligase Ligand 48

PROTACAR Degrader-9 (Compound c6) is a CRBN-based PROTAC that selectively degrades the androgen receptor (AR) . It demonstrates potent activity in vitro, degrading AR in human dermal papilla cells with a DC50 of 262.38 nM, making it a valuable tool for prostate cancer and androgenetic alopecia research.