KT-253
KT-253 is a bifunctional small molecule that stabilizes p53 and potently degrades MDM2 via cereblon recruitment (DC50=0.4 nM) . It demonstrates potent anti-proliferative activity (IC50=0.3 nM in RS4;11 cells), inducing G2/M arrest and apoptosis, with confirmed antitumor efficacy in mouse models.
Product Specifications
CAS Number
2713618-08-5
Field of Research
Cell Biology, Pharmacology & Drug Discovery
Smiles
O=C1[C@@]2 (C3 (N[C@@H] (C (N[C@@H]4CC[C@@H] (C (=O) N5CCC (CC5) C=6C=C7C (=CC6) N (C (=O) N7C) C8C (=O) NC (=O) CC8) CC4) =O) [C@@H]2C9=C (F) C (Cl) =CC=C9) CCCCC3) C=%10C (N1) =CC (Cl) =CC%10
Molecular Formula
C48H52Cl2FN7O6
Molecular Weight
912.874
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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