(+) -Mcl-1 inhibitor 22

(+) -Mcl-1 inhibitor 22 (Example 37) is a potent and selective small molecule that disrupts MCL-1's interaction with pro-apoptotic proteins, inducing apoptosis. It exhibits robust anti-proliferative activity in diverse cancer cell lines in vitro and has shown efficacy in xenograft tumor models in vivo, supporting its use in oncology research.