NDM-1 inhibitor-8
NDM-1 inhibitor-8 (Compound 18b) is a covalent small molecule inhibitor of New Delhi metallo-β-lactamase-1 with an IC50 of 7.03 μM. It demonstrates synergistic antibacterial activity with meropenem in vitro and exhibits anti-infective efficacy in mouse infection models, supporting research into combating carbapenem-resistant bacteria.
Product Specifications
Field of Research
Infectious Disease & Virology, Pharmacology & Drug Discovery
Smiles
C1C (=C (N2[C@H] (S1) [C@@H] (C2=O) NCC3=CC (=CC (=C3) Cl) Cl) C (=O) O) C[Se]C4=CC=CC=C4C (=O) NC5=CC=CC=C5
Molecular Formula
C28H23Cl2N3O4SSe
Molecular Weight
647.43
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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