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RORγt inhibitor 4

Compound 9a is a potent, orally bioavailable, and brain-penetrant RORγt inverse agonist. It demonstrates efficacy in Th17-driven disease models, including the amelioration of clinical symptoms in experimental autoimmune encephalomyelitis (EAE) in vivo.

Product Specifications

CAS Number

1426803-07-7

Field of Research

Metabolism Research, Pharmacology & Drug Discovery

Smiles

O=C (NC=1C=C (Cl) C (=C (Cl) C1) C=2C=CC=CC2OC (F) (F) F) CC3=CC=C (C=C3) S (=O) (=O) C

Molecular Formula

C22H16Cl2F3NO4S

Molecular Weight

518.333

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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