DSM1465

DSM1465 (Compound 82) is a highly potent and selective PfDHODH inhibitor, exhibiting an IC50 of 15 nM. It demonstrates potent antimalarial activity against P. falciparum 3D7 parasites in vitro (EC50 = 1.4 nM) and shows significant efficacy in humanized mouse models in vivo, supporting its use in malaria drug discovery research.