DSM1465
DSM1465 (Compound 82) is a highly potent and selective PfDHODH inhibitor, exhibiting an IC50 of 15 nM. It demonstrates potent antimalarial activity against P. falciparum 3D7 parasites in vitro (EC50 = 1.4 nM) and shows significant efficacy in humanized mouse models in vivo, supporting its use in malaria drug discovery research.
Product Specifications
Field of Research
Infectious Disease & Virology, Metabolism Research
Smiles
ClC1=C (C (F) (F) F) N=CC ([C@] (C2=C3C (C (N (C4CC4) C=N3) =O) =NN2C) (O) C (F) (F) F) =C1
Molecular Formula
C17H12ClF6N5O2
Molecular Weight
467.753
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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