KWR095
KWR095 is a potent, orally bioavailable WRN inhibitor with an IC50 of 0.032 μM against its ATPase activity. It blocks WRN's helicase function, suppressing cancer cell growth in vitro, and is a valuable tool for studying DNA repair mechanisms and synthetic lethality in MSI-H cancer models.
Product Specifications
CAS Number
3057980-16-9
Field of Research
Cell Biology, Molecular Biology
Smiles
O=C (C1=NC=CC=2C=CNC21) N3CCN (C=4C (=O) N5N=C (N=C5N (C4CC) CC (=O) NC6=CC=C (C=C6Cl) C (F) (F) F) C7=CCOCC7) CC3
Molecular Formula
C33H31ClF3N9O4
Molecular Weight
710.105
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
134451-ML550 100 µL
TIMM8A (Mitochondrial Import Inner Membrane Translocase Subunit Tim8 A, Deafness Dystonia Protein 1, X-linked Deafness Dystonia Protein, DDP, DDP1, TIM8A) (MaxLight 550)
Sign In for Pricing
View Details 
K6732203 1.0 µg DNA
Agpat2 sgRNA CRISPR Lentivector (Rat) (Target 2)
Sign In for Pricing
View Details EKC40862 96 Tests
Mouse Pulmonary Surfactant-Associated Protein B (Sp-B) Elisa Kit
Sign In for Pricing
View Details