PROTAC cGAS degrader-1
PROTAC cGAS degrader-1 (TH35) is a potent and selective degrader with DC50 values of 0.9 μM (THP-1) and 4.6 μM (RAW 264.7), effectively suppressing dsDNA-induced cGAS signaling. Its anti-inflammatory activity makes it a valuable tool for studying cGAS-driven pathologies like autoimmune diseases in cellular models.
Product Specifications
Field of Research
Immunology & Inflammation, Infectious Disease & Virology, Pharmacology & Drug Discovery
Molecular Formula
C36H33Cl2N7O5
Molecular Weight
714.6
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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