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PROTAC cGAS degrader-1

PROTAC cGAS degrader-1 (TH35) is a potent and selective degrader with DC50 values of 0.9 μM (THP-1) and 4.6 μM (RAW 264.7), effectively suppressing dsDNA-induced cGAS signaling. Its anti-inflammatory activity makes it a valuable tool for studying cGAS-driven pathologies like autoimmune diseases in cellular models.

Product Specifications

Field of Research

Immunology & Inflammation, Infectious Disease & Virology, Pharmacology & Drug Discovery

Molecular Formula

C36H33Cl2N7O5

Molecular Weight

714.6

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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