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PROTAC CDK9 degrader-11

PROTAC CDK9 degrader-11 (C3) is an orally bioavailable, potent degrader (DC50 = 1.09 nM) demonstrating nanomolar cytotoxicity in SCLC models. It induces G0/G1 arrest, inhibits invasion in vitro, and shows in vivo antitumor efficacy in an NCI-H446 xenograft model, supporting its use in oncology and targeted protein degradation research.

Product Specifications

CAS Number

3039540-19-4

Field of Research

Cell Biology, Epigenetics & Chromatin, Pharmacology & Drug Discovery

Smiles

O=C (NC1=CNN=C1C (=O) NC2CCN (C (=O) CN3CCC (CN4CCN (C=5C=CC=C (C5) NC6C (=O) NC (=O) CC6) CC4) CC3) CC2) C=7C (Cl) =CC=CC7Cl

Molecular Formula

C39H48Cl2N10O5

Molecular Weight

807.768

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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