KWR137
KWR137 is a potent WRN degrader (IC50 = 8 nM) with antiproliferative activity in MSI-H cells, such as SW48 (GI50 = 509 nM), and demonstrates antitumor efficacy in xenograft models, making it a valuable tool for cancer research, particularly in DNA damage response and synthetic lethality studies.
Product Specifications
Field of Research
Cell Biology, Molecular Biology
Smiles
O=C1C (N2CCN (C (C3=CC (N=CC=C4) =C4N3) =O) CC2) =C (CC) N (CC (NC5=CC=C (C (F) (F) F) C=C5Cl) =O) C6=NC (C7=CCOCC7) =NN61
Molecular Formula
C33H31ClF3N9O4
Molecular Weight
710.105
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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