NU227326
NU227326 is a potent PROTAC degrader of IDO1, demonstrating cellular DC50 values in the low nanomolar range in U87 and GBM43 glioblastoma cells. Its favorable pharmacokinetic profile, including extended brain half-life, supports its application in researching IDO1's role in cancer immunology and for potential in vivo studies in glioma models.
Product Specifications
CAS Number
3048196-52-4
Field of Research
Metabolism Research, Pharmacology & Drug Discovery
Smiles
O=C1C=2C (C (=O) N1C3C (=O) NC (=O) CC3) =CC=C (C2) N4CCN (CC4) C5CCN (CC (=O) N6CCC (OC7=CC (NC ([C@H] (C) [C@]8 (CC[C@H] (CC8) C=9C%10=C (N=CC9) C=CC (F) =C%10) [H]) =O) =CC=C7) CC6) CC5
Molecular Formula
C53H61FN8O7
Molecular Weight
941.099
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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