FXR agonist 12
FXR agonist12 (Compound C7) is an orally bioavailable small molecule that modulates bile acid homeostasis by repressing synthesis genes and inducing transport genes in HepG2 cells. It demonstrates efficacy in preclinical models, ameliorating ANIT-induced cholestasis and reducing liver injury and fibrosis in a mouse model of NASH.
Product Specifications
CAS Number
1831862-88-4
Field of Research
Immunology & Inflammation; Pharmacology & Drug Discovery, Metabolism Research
Smiles
C[C@@]12[C@@]3 ([C@] ([C@]4 ([C@] (C) (CC3) [C@@] ([C@@H] (CCC (O) =O) C) (CC4) [H]) [H]) ([C@H] (O) [C@H] (CC) [C@@]1 (CCCC2) [H]) [H]) [H]
Molecular Formula
C26H44O3
Molecular Weight
404.626
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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