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DNMT1-IN-5

DNMT1-IN-5 (Compound 55) is a dual inhibitor of DNMT1 and DNMT3A with IC50 values of 2.42 μM and 14.4 μM, respectively. It demonstrates broad antiproliferative activity in cancer cell lines, induces cell cycle arrest and apoptosis, and shows in vivo efficacy in a TMD-8 xenograft model.

Product Specifications

CAS Number

2982511-19-1

Field of Research

Cell Biology, Epigenetics & Chromatin

Smiles

FC1=NC=CC (=C1) C=2N=C (NC3CCN (C) CC3) C=4C=CN (C4N2) CCCN5CCCC5

Molecular Formula

C24H32FN7

Molecular Weight

437.556

Storage Conditions

-20°C

Notes

For research use only.

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