ATX-IN-1

ATX-IN-1 (compound 35) is a potent, orally bioavailable ATX inhibitor (IC50 = 0.7 nM) with anti-inflammatory and anti-fibrotic properties. It suppresses the TGF-β/Smad pathway and collagen deposition, demonstrating efficacy in a bleomycin-induced pulmonary fibrosis mouse model, making it a valuable tool for fibrosis and inflammation research.