Mal-PEG4-VC-PAB-EDA-PNU159682
Mal-PEG4-VC-PAB-EDA-PNU159682 is a thiol-reactive linker-drug conjugate designed for constructing antibody-drug conjugates (ADCs) . Its payload, PNU159682, is a potent DNA topoisomerase II inhibitor, enabling targeted cytotoxicity in cancer research, as demonstrated in both in vitro and in vivo preclinical ADC studies.
Product Specifications
CAS Number
2571582-15-3
Field of Research
Stem Cell & Developmental Biology
Smiles
O ([C@@H]1C2=C (C (O) =C3C (=C2O) C (=O) C=4C (C3=O) =CC=CC4OC) C[C@] (C (NCCNC (OCC5=CC=C (NC ([C@@H] (NC ([C@@H] (NC (CCOCCOCCOCCOCCN6C (=O) C=CC6=O) =O) [C@@H] (C) C) =O) CCCNC (N) =O) =O) C=C5) =O) =O) (O) C1) [C@H]7C[C@@]8 (N9[C@] (O[C@@]8 ([C@H] (C) O7) [H]) ([C@@H] (OC) OCC9) [H]) [H]
Molecular Formula
C67H87N9O24
Molecular Weight
1402.45
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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