Ac-Exatecan
Ac-Exatecan is an acetylated derivative of the topoisomerase I inhibitor Exatecan (DX-8951), which exhibits antitumor activity with an IC50 of 2.2 μM. This compound is utilized in cancer research to study TOP1 inhibition and has been investigated in both in vitro cytotoxicity assays and in vivo tumor model studies.
Product Specifications
CAS Number
2922852-48-8
Product Name Alternative
ADC Cytotoxin, ADCCytotoxin, Ac-DX-8951
Field of Research
Molecular Biology, Pharmacology & Drug Discovery
Purity
97.09% (May vary between batches)
Solubility
DMSO:80 mg/mL (167.55 mM)
Smiles
N (C (C) =O) [C@@H]1C2=C3C (C=4N (C3) C (=O) C5=C (C4) [C@] (CC) (O) C (=O) OC5) =NC=6C2=C (CC1) C (C) =C (F) C6
Molecular Formula
C26H24FN3O5
Molecular Weight
477.48
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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