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Ac-Exatecan

Ac-Exatecan is an acetylated derivative of the topoisomerase I inhibitor Exatecan (DX-8951), which exhibits antitumor activity with an IC50 of 2.2 μM. This compound is utilized in cancer research to study TOP1 inhibition and has been investigated in both in vitro cytotoxicity assays and in vivo tumor model studies.

Product Specifications

CAS Number

2922852-48-8

Product Name Alternative

ADC Cytotoxin, ADCCytotoxin, Ac-DX-8951

Field of Research

Molecular Biology, Pharmacology & Drug Discovery

Purity

97.09% (May vary between batches)

Solubility

DMSO:80 mg/mL (167.55 mM)

Smiles

N (C (C) =O) [C@@H]1C2=C3C (C=4N (C3) C (=O) C5=C (C4) [C@] (CC) (O) C (=O) OC5) =NC=6C2=C (CC1) C (C) =C (F) C6

Molecular Formula

C26H24FN3O5

Molecular Weight

477.48

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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