Langerin / CD207 Recombinant Rabbit Monoclonal Antibody [PSH04-60]
Langerin (CD207) is a type II transmembrane protein which is encoded by the CD207 gene in humans. It was discovered by scientists Sem Saeland and Jenny Valladeau as a main part of Birbeck granules. Langerin is C-type lectin receptor on Langerhans cells (LCs) and in mice also on dermal interstitial CD103+ dendritic cells (DC) and on resident CD8+ DC in lymph nodes. Langerin has similar function and structure as a DCs surface protein DC-SIGN (CD209). Both receptors bind similar antigens via the CRD, for instance Mycobacterium tuberculosis and HIV-1. However, whereas HIV-1 binding to langerin leads to the elimination of the virus, HIV-1 binding to DC-SIGN leads to infection of the cell.
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
CD207, CLEC4K
Swiss Prot
Q9UJ71 Human
Cellular Locus
Membrane.
Host
Rabbit
Species Reactivity
Human
Immunogen
Synthetic peptide within human Langerin aa 1-43 / 328.
Isotype
IgG
Clone
PSH04-60
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB, IHC-P, IF-Cell, IF-Tissue
Positive Control
Human lymph nodes tissue, human skin tissue, human tonsil tissue, 293T cells transfected with CD207/Langerin.
Concentration
1 mg/mL
Dilution
WB: 1:1,000 ;IHC-P: 1:4,000 ;IF-Cell: 1:2,500 ;IF-Tissue: 1:200-1:1,000
Purity
Protein A affinity purified.
Form
Liquid
Buffer
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 37 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
Yes
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