HER2-IN-15

HER2-IN-15 (Compound 1) is an inhibitor for HER2, which inhibits the Her YVMA exon 20 insertion mutation (HER2 YVMA) with an IC50 IC50 [1].

Product Specifications

UNSPSC

12352005

Target

EGFR

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/her2-in-15.html

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CC1=CC(NC2=NC=NN3C=CC(C4CN(C4)C(/C=C/CN(C)C)=O)=C23)=CC=C1OC5=CC6=NC=NN6C=C5

Molecular Formula

C28H29N9O2

Molecular Weight

523.59

References & Citations

[1]Svitlana KULYK, et al., Compounds and methods for modulating her2. Patent WO2024044570.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

ErbB2/HER2

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