Ferroptosis/apoptosis inducer-1

Ferroptosis/apoptosis inducer-1 (compound 4d) is a dual inducer of apoptosis and ferroptosis. Ferroptosis/apoptosis inducer-1 induces apoptosis and ferroptosis by reducing mitochondrial membrane potential and downregulating GPX4. Ferroptosis/apoptosis inducer-1 can significantly inhibit the proliferation and metastasis of triple-negative breast cancer (TNBC) both in vitro and in vivo, playing an important role in cancer research[1].

CC(C(OC)=CC1=O)=C(O1)/C=C/C=C/C=C/[C@H](O[C@@]2([C@H]([C@@]3(O[C@@H]2CC)C)OC(C)=O)C)[C@@H]3OC(CCC(OC/C=C/COC4=NO[N+]([O-])=C4S(=O)(C5=CC=CC=C5)=O)=O)=O

[1]Lie-Feng Ma, et al. "Discovery of NO Donor-Aurovertin Hybrids as Dual Ferroptosis and Apoptosis Inducers for Treating Triple Negative Breast Cancer." Journal of Medicinal Chemistry (2024).