Ferroptosis/apoptosis inducer-1
Product Specifications
UNSPSC Description
Ferroptosis/apoptosis inducer-1 (compound 4d) is a dual inducer of apoptosis and ferroptosis. Ferroptosis/apoptosis inducer-1 induces apoptosis and ferroptosis by reducing mitochondrial membrane potential and downregulating GPX4. Ferroptosis/apoptosis inducer-1 can significantly inhibit the proliferation and metastasis of triple-negative breast cancer (TNBC) both in vitro and in vivo, playing an important role in cancer research[1].
Target Antigen
Apoptosis; Ferroptosis
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ferroptosis-apoptosis-inducer-1.html
Smiles
CC(C(OC)=CC1=O)=C(O1)/C=C/C=C/C=C/[C@H](O[C@@]2([C@H]([C@@]3(O[C@@H]2CC)C)OC(C)=O)C)[C@@H]3OC(CCC(OC/C=C/COC4=NO[N+]([O-])=C4S(=O)(C5=CC=CC=C5)=O)=O)=O
Molecular Weight
854.87
References & Citations
[1]Lie-Feng Ma, et al. "Discovery of NO Donor-Aurovertin Hybrids as Dual Ferroptosis and Apoptosis Inducers for Treating Triple Negative Breast Cancer." Journal of Medicinal Chemistry (2024).
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-163889/Ferroptosis-apoptosis-inducer-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-163889/
Clinical Information
No Development Reported
Curated Selection
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