UBP 302

UBP 302 is a potent and selective GLUK5-subunit containing kainate receptor antagonist (apparent Kd=402 nM), and displays very little affinity on GluK2 (GluR6) kainate receptors. Anxiolytic effects[1][2][3].

Product Specifications

CAS Number

[745055-91-8]

UNSPSC

12352005

Hazard Statement

H302

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ubp-302.html

Concentration

10mM

Purity

99.75

Solubility

DMSO : 16.67 mg/mL (ultrasonic)

Smiles

O=C(N(C=CC1=O)C[C@H](N)C(O)=O)N1CC2=C(C=CC=C2)C(O)=O

Molecular Formula

C15H15N3O6

Molecular Weight

333.30

Precautions

H302

References & Citations

[1]More JC, et al. Characterisation of UBP296: a novel, potent and selective kainate receptor antagonist. Neuropharmacology. 2004 Jul;47 (1) :46-64.|[2]Dolman NP, et al. Synthesis and pharmacology of willardiine derivatives acting as antagonists of kainate receptors. J Med Chem. 2005 Dec 1;48 (24) :7867-81.|[3]Apland JP, et al. The limitations of diazepam as a treatment for nerve agent-induced seizures and neuropathology in rats: comparison with UBP302. J Pharmacol Exp Ther. 2014 Nov;351 (2) :359-72.