(R) -Selisistat

(R) -Selisistat ((R) -EX-527) is a R-enantiomer of Selisistat. Selisistat (EX-527) is a potent and selective SIRT1 inhibitor with IC50 of 98 nM.

Product Specifications

CAS Number

[848193-69-1]

Product Name Alternative

(R) -EX-527

UNSPSC

12352005

Hazard Statement

H302, H317

Target

Sirtuin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/EX-527-R-enantiomer.html

Concentration

10mM

Purity

98.03

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C([C@H]1C(NC2=C3C=C(Cl)C=C2)=C3CCC1)N

Molecular Formula

C13H13ClN2O

Molecular Weight

248.71

Precautions

H302, H317

References & Citations

[1]Napper AD, et al. Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1. J Med Chem. 2005 Dec 15;48 (25) :8045-54.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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