(R)-Selisistat
Product Specifications
UNSPSC Description
(R)-Selisistat ((R)-EX-527) is a R-enantiomer of Selisistat. Selisistat (EX-527) is a potent and selective SIRT1 inhibitor with IC50 of 98 nM.
Target Antigen
Sirtuin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/EX-527-R-enantiomer.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C([C@H]1C(NC2=C3C=C(Cl)C=C2)=C3CCC1)N
Molecular Weight
248.713
References & Citations
[1]Napper AD, et al. Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1. J Med Chem. 2005 Dec 15;48(25):8045-54.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-15452B/R-Selisistat-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-15452B/R-Selisistat-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
848193-69-1
Available Sizes
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