(R) -Selisistat
(R) -Selisistat ((R) -EX-527) is a R-enantiomer of Selisistat. Selisistat (EX-527) is a potent and selective SIRT1 inhibitor with IC50 of 98 nM.
Product Specifications
CAS Number
848193-69-1
Product Name Alternative
(R) -EX-527
UNSPSC
12352005
Hazard Statement
H302, H317
Target
Sirtuin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/EX-527-R-enantiomer.html
Concentration
10mM
Purity
98.03
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C([C@H]1C(NC2=C3C=C(Cl)C=C2)=C3CCC1)N
Molecular Formula
C13H13ClN2O
Molecular Weight
248.71
Precautions
H302, H317
References & Citations
[1]Napper AD, et al. Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1. J Med Chem. 2005 Dec 15;48 (25) :8045-54.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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