L-690330 (hydrate)
Product Specifications
UNSPSC Description
L-690330 hydrate is a competitive inhibitor of inositol monophosphatase (IMPase) with Kis of 0.27 and 0.19 μM for recombinant human and bovine IMPase, 0.30 and 0.42 μM for human and bovine frontal cortex IMPase, respectively. L-690330 hydrate exhibits 10-fold more sensitive than mouse and rat IMPase[1].
Target Antigen
Phosphatase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/l-690330-hydrate.html
Purity
98.0
Solubility
DMSO : ≥ 100 mg/mL|H2O : ≥ 100 mg/mL
Smiles
OC1=CC=C(OC(P(O)(O)=O)(P(O)(O)=O)C)C=C1.O
Molecular Weight
316.14
References & Citations
[1]Atack JR, et al. In vitro and in vivo inhibition of inositol monophosphatase by the bisphosphonate L-690,330. J Neurochem. 1993 Feb;60(2):652-8.|[2]Cárdenas C, et al. Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria.Cell. 2010 Jul 23;142(2):270-83.|[3]Shtein L, et al. The inositol monophosphatase inhibitor L-690,330 affects pilocarpine-behavior and the forced swim test.Psychopharmacology (Berl). 2013 Jun;227(3):503-8.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-101075A/L-690330-hydrate-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-101075A/L-690330-hydrate-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2930564-26-2
Available Sizes
Curated Selection
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