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Fomesafen-d3

Fomesafen-d3 is the deuterium-labeled Fomesafen. Fomesafen is an orally active herbicide. Fomesafen inhibits protoporphyrinogen oxidase (PPO). Fomesafen induces Apoptosis and increases ROS. Fomesafen exhibits developmental toxicity, immunotoxicity, and neurotoxicity. It induces precancerous lesions in the liver and hepaturoporphyria in mice. Fomesafen is used to control broadleaf weeds in soybean fields, rubber plantations, and orchards[1][2][3][4][5][6].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Herbicide; Isotope-Labeled Compounds; Protoporphyrinogen IX oxidase; Reactive Oxygen Species (ROS)

Type

Isotope-Labeled Compounds

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others

Field of Research

Cancer; Metabolic Disease; Neurological Disease

Solubility

10 mM in DMSO

Smiles

O=C(NS(=O)(C([2H])([2H])[2H])=O)C1=CC(OC2=CC=C(C(F)(F)F)C=C2Cl)=CC=C1[N+]([O-])=O

Molecular Formula

C15H7D3ClF3N2O6S

Molecular Weight

441.78

References & Citations

[1]Li-Xia Zhao, et al. Novel Thiazole Phenoxypyridine Derivatives Protect Maize From Residual Pesticide Injury Caused by PPO-Inhibitor Fomesafen. Biomolecules. 2019 Sep 20;9 (10) :514.|[2]MACAR O, et al. FOMESAFEN-INDUCED MERISTEMATIC CELL DAMAGES IN ALLIUM CEPA L. (ONION) [J]. |[3]Xu Z, et al. Effect of fomesafen on the embryonic development of zebrafish. Chemosphere. 2020 Nov;259:127380. |[4]Krijt J, et al. Experimental hepatic uroporphyria induced by the diphenyl-ether herbicide fomesafen in male DBA/2 mice. Toxicol Appl Pharmacol. 2003 May 15;189 (1) :28-38. |[5]Krijt J, et al. Liver preneoplastic changes in mice treated with the herbicide fomesafen. Hum Exp Toxicol. 1999 May;18 (5) :338-44. |[6]Zhang Q, et al. Oxidative stress and lipid peroxidation in the earthworm Eisenia fetida induced by low doses of fomesafen. Environ Sci Pollut Res Int. 2013 Jan;20 (1) :201-8.

Shipping Conditions

Room temperature

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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