D, L-erythro-PDMP (hydrochloride)

D, L-erythro-PDMP hydrochloride is an erythro isomer of PDMP. D, L-erythro-PDMP hydrochloride causes growth inhibition of cultured rabbit skin fibroblasts. PDMP is an effective inhibitor of UDP-glucose:ceramide glucosyltransferase[1][2].

Product Specifications

CAS Number

[80943-40-4]

UNSPSC

12352005

Target

Glucosylceramide Synthase (GCS)

Type

Reference compound

Related Pathways

Neuronal Signaling

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/d-l-erythro-pdmp-hydrochloride.html

Purity

98.45

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O[C@@H](C1=CC=CC=C1)[C@H](NC(CCCCCCCCC)=O)CN2CCOCC2.[H]Cl

Molecular Formula

C23H39ClN2O3

Molecular Weight

427.02

References & Citations

[1]Uemura K, et al. Effect of an inhibitor of glucosylceramide synthesis on cultured rabbit skin fibroblasts. J Biochem. 1990 Oct;108 (4) :525-30. |[2]Abe A, et al. Induction of glucosylceramide synthase by synthase inhibitors and ceramide. Biochim Biophys Acta. 1996 Feb 16;1299 (3) :333-41.