D, L-erythro-PDMP (hydrochloride)
D, L-erythro-PDMP hydrochloride is an erythro isomer of PDMP. D, L-erythro-PDMP hydrochloride causes growth inhibition of cultured rabbit skin fibroblasts. PDMP is an effective inhibitor of UDP-glucose:ceramide glucosyltransferase[1][2].
Product Specifications
CAS Number
[80943-40-4]
UNSPSC
12352005
Target
Glucosylceramide Synthase (GCS)
Type
Reference compound
Related Pathways
Neuronal Signaling
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/d-l-erythro-pdmp-hydrochloride.html
Purity
98.45
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O[C@@H](C1=CC=CC=C1)[C@H](NC(CCCCCCCCC)=O)CN2CCOCC2.[H]Cl
Molecular Formula
C23H39ClN2O3
Molecular Weight
427.02
References & Citations
[1]Uemura K, et al. Effect of an inhibitor of glucosylceramide synthesis on cultured rabbit skin fibroblasts. J Biochem. 1990 Oct;108 (4) :525-30. |[2]Abe A, et al. Induction of glucosylceramide synthase by synthase inhibitors and ceramide. Biochim Biophys Acta. 1996 Feb 16;1299 (3) :333-41.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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