JH-LPH-28
Product Specifications
UNSPSC Description
JH-LPH-28, a sulfonyl piperazine analog, is a potent UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH inhibitor. JH-LPH-28 displays outstanding antibiotic activity with a MIC value of 0.83 μg/mL[1].
Target Antigen
Antibiotic; Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/jh-lph-28.html
Purity
98.56
Solubility
DMSO : 12.5 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
CC(N1CCC2=C1C=CC(S(=O)(N3CCN(C4=CC(F)=CC(C(F)(F)F)=C4)CC3)=O)=C2)=O
Molecular Weight
471.47
References & Citations
[1]Cho J, et al. Structural basis of the UDP-diacylglucosamine pyrophosphohydrolase LpxH inhibition by sulfonyl piperazine antibiotics. Proc Natl Acad Sci U S A. 2020 Feb 25;117(8):4109-4116.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-130837/JH-LPH-28-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-130837/JH-LPH-28-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2414592-36-0
Available Sizes
Curated Selection
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