BCN-HS-PEG2-bis (PNP)
BCN-HS-PEG2-bis (PNP) (Compound 62) is a p-nitrophenyl-containing ADC linker that can be used to further couple ADC cytotoxins with peptide linkers. BCN-HS-PEG2-bis (PNP) can conjugate with vc-PABC-MMAE to form Drug-Linker Conjugates for ADC[1].
Product Specifications
CAS Number
2126749-95-7
UNSPSC
12352005
Target
ADC Linker
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bcn-hs-peg2-bis-pnp.html
Smiles
O=[N+]([O-])C(C=C1)=CC=C1OC(OCCN(CCOC(OC2=CC=C(C=C2)[N+]([O-])=O)=O)C(OCCOCCNS(NC(OC[C@H]3[C@]4([H])[C@@]3([H])CCC#CCC4)=O)(=O)=O)=O)=O
Molecular Formula
C34H39N5O17S
Molecular Weight
821.76
References & Citations
[1]Sander Sebastiaan Van Berkel, et al. Antibody-conjugates with improved therapeutic index for targeting cd30 tumours and method for improving therapeutic index of antibody-conjugates. Patent. WO2017137458.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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