EGFR/AURKB-IN-1
EGFR/AURKB-IN-1 (compound 7) is a dual-targeted EGFR/AURKB inhibitor, and inhibits the phpsphorylations of L858R EGFR and AURKB with IC50s of 0.07 and 1.1, respectively. EGFR/AURKB-IN-1 occupies the hydrophobic region I or the αC-helix out pocket of EGFR and the back pocket of AURKB, inhibiting the growth, division and metastasis of tumor cells, thus can be used for cancer research[1].
Product Specifications
CAS Number
[3008543-34-5]
UNSPSC
12352005
Target
Aurora Kinase; EGFR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-aurkb-in-1.html
Purity
99.43
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CN1N=CC=C1C2=CC3=C(N=CN=C3N2)NC4=CC=C(C=C4)OCC5=CC=CC=C5
Molecular Formula
C23H20N6O
Molecular Weight
396.44
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Explore Other Products
Browse additional items from our catalog
GABBR2, CT (GABBR2, GPR51, GPRC3B, Gamma-aminobutyric acid type B receptor subunit 2, G-protein coupled receptor 51, HG20) (AP)
GABBR2, CT (GABBR2, GPR51, GPRC3B, Gamma-aminobutyric acid type B receptor subunit 2, G-protein coupled receptor 51, HG20) (AP)
SOCS5 (Suppressor of Cytokine Signaling 5, SOCS-5, Cytokine-inducible SH2 Protein 6, CIS6, CIS-6, CISH6, Cytokine-inducible SH2-containing Protein 5, CISH5, KIAA0671) (HRP)
