CORM-A1

CORM-A1 (Sodium boranocarbonate) is a water-soluble carbon monoxide (CO) releasing molecule that facilitates the study of CO's effects on cellular systems. As CO is produced by the degradation of heme by heme oxygenase, it serves as a crucial gaseous signaling mediator in mammalian cells. CORM-A1 not only possesses antioxidant and anti-inflammatory properties but also modulates CO release in a pH and temperature-dependent manner, promoting mild vasodilation and hypotension. Additionally, CORM-A1 has been shown to provide cellular protection in primary cultures of astrocytes under oxidative stress, enhancing autophagy due to its boron content.