AF64394
AF64394 is a GPR3 inverse agonist, with a pIC50 of 7.3.
Product Specifications
CAS Number
[1637300-25-4]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Orphan GPCR; Orphan Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/AF64394.html
Purity
98.02
Solubility
DMSO : ≥ 125 mg/mL
Smiles
ClC1=CC(OC(C)C)=C(CNC2=CC(C3=CC=CC=C3)=NC4=NC=NN42)C=C1
Molecular Formula
C21H20ClN5O
Molecular Weight
393.87
Precautions
H302, H315, H319, H335
References & Citations
[1]Jensen T, et al. The identification of GPR3 inverse agonist AF64394; the first small molecule inhibitor of GPR3 receptor function. Bioorg Med Chem Lett. 2014 Nov 15;24 (22) :5195-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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