GGTI-2417

GGTI-2417 is a potent and selective inhibitor of GGTase I. GGTI-2417 inhibits the Cdk2-mediated phosphorylation of p27Kip1 at Thr187 and accumulates p27Kip1 in the nucleus. GGTI-2417 also induces breast cancer cell apoptosis[1].

Product Specifications

CAS Number

[501010-05-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; ROS Kinase

Type

Reference compound

Related Pathways

Apoptosis; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ggti-2417.html

Purity

98.97

Solubility

DMSO : 100 mg/mL (ultrasonic) |Methanol : 125 mg/mL (ultrasonic)

Smiles

CC(C)C[C@@H](C(OC)=O)NC(N1[C@@H](CC2=CC=CC=C2)C(N(CC3=C(C)N=CN3)CC1)=O)=O

Molecular Formula

C24H33N5O4

Molecular Weight

455.55

Precautions

H302, H315, H319, H335

References & Citations

[1]Kazi A, et al. Blockade of protein geranylgeranylation inhibits Cdk2-dependent p27Kip1 phosphorylation on Thr187 and accumulates p27Kip1 in the nucleus: implications for breast cancer therapy. Mol Cell Biol. 2009 Apr;29 (8) :2254-63.