GGTI-2417
GGTI-2417 is a potent and selective inhibitor of GGTase I. GGTI-2417 inhibits the Cdk2-mediated phosphorylation of p27Kip1 at Thr187 and accumulates p27Kip1 in the nucleus. GGTI-2417 also induces breast cancer cell apoptosis[1].
Product Specifications
CAS Number
501010-05-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; ROS Kinase
Type
Reference compound
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ggti-2417.html
Purity
98.97
Solubility
DMSO : 100 mg/mL (ultrasonic) |Methanol : 125 mg/mL (ultrasonic)
Smiles
CC(C)C[C@@H](C(OC)=O)NC(N1[C@@H](CC2=CC=CC=C2)C(N(CC3=C(C)N=CN3)CC1)=O)=O
Molecular Formula
C24H33N5O4
Molecular Weight
455.55
Precautions
H302, H315, H319, H335
References & Citations
[1]Kazi A, et al. Blockade of protein geranylgeranylation inhibits Cdk2-dependent p27Kip1 phosphorylation on Thr187 and accumulates p27Kip1 in the nucleus: implications for breast cancer therapy. Mol Cell Biol. 2009 Apr;29 (8) :2254-63.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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