T025
T025 is an orally active and highly potent inhibitor of Cdc2-like kinase (CLKs), with Kd values of4.8, 0.096, 6.5, 0.61, 0.074, 1.5 and 32 nM for CLK1, CLK2, CLK3, CLK4, DYRK1A, DYRK1B and DYRK2, respectively. T025 induces caspase-3/7-mediated cell apoptosis. T025 reduces CLK-dependent phosphorylation. T025 exerts anti-proliferative activities in both hematological and solid cancer cell lines (IC50 values: 30-300 nM) . T025 has an anti-tumor efficiency, mainly for MYC-driven disease research.
Product Specifications
CAS Number
2407433-00-3
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 8.25 mg/mL (21.57 mM; Ultrasonic)
Smiles
CNc1nc (NCc2ncccn2) c2c (c[nH]c2n1) -c1ccc2ncccc2c1
Molecular Formula
C21H18N8
Molecular Weight
382.42
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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