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AMG-1694

AMG-1694 is a potent glucokinase–glucokinase regulatory protein (GK-GKRP) disruptors and promotes the dissociation of the GK-GKRP complex with an IC50 of 7 nM, indirectly increasing GK enzymatic activity. AMG-1694 potently reverses the inhibitory effect of GKRP on GK activity and promotes GK translocation. AMG-1694 normalizes blood glucose levels in several rodent models of diabetes and lowes blood glucose restricted to diabetic and not normoglycaemic animals.

Product Specifications

CAS Number

1361217-07-3

Purity

>98% (HPLC)

Smiles

C ([C@@H]1N (CCN (S (=O) (=O) C2=CC=CS2) C1) C3=CC=C ([C@@] (C (F) (F) F) (C) O) C=C3) N4[C@@H] (C) COCC4

Molecular Formula

C23H30F3N3O4S2

Molecular Weight

533.63

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Available Sizes

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