HS-27
HS-27, a fluorescently-tethered Hsp90 inhibitor, assays surface Hsp90 expression on intact tissue specimens. HS-27 is made up of the core elements of SNX-5422, an Hsp90 inhibitor, tethered via a PEG linker to a fluorescein derivative (fluorescein isothiocyanate or FITC), that binds to ectopically expressed Hsp90. HS-27 has potential use in a see-and-treat paradigm in breast cancer.
Product Specifications
CAS Number
1562024-11-6
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 100 mg/mL (100.69 mM; Ultrasonic)
Smiles
Cc1nn (c2CC (C) (C) CC (=O) c12) -c1ccc (C (N) =O) c (NCCCOCCOCCOCCOCCOCCCNC (=S) Nc2ccc3c (c2) C (=O) OC32c3ccc (O) cc3Oc3cc (O) ccc23) c1
Molecular Formula
C52H60N6O12S
Molecular Weight
993.13
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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