SJFα
SJFα is a 13-atom linker PROTAC based on von Hippel-Lindau ligand. SJFα degrades p38α with a DC50 of 7.16 nM, but is far less effective at degrading p38δ (DC50=299 nM) and does not degrade the other p38 isoforms (β and γ) at concentrations up to 2.5 μM.
Product Specifications
CAS Number
2254609-27-1
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 100 mg/mL (89.26 mM; Ultrasonic (<60°C)
Smiles
C (NC1=CC (F) =C (OC=2C3=C (C=C (OCCCCOCCCCOCC (N[C@H] (C (=O) N4[C@H] (C (NCC5=CC=C (C=C5) C=6SC=NC6C) =O) C[C@@H] (O) C4) [C@] (C) (C) C) =O) C (OC) =C3) N=CC2) C=C1) (=O) C7 (C (NC8=CC=C (F) C=C8) =O) CC7
Molecular Formula
C59H67F2N7O11S
Molecular Weight
1120.27
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Available Sizes
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