LE135
LE135 is a potent RAR antagonist that binds selectively to RARα (Ki of 1.4 μM) and RARβ (Ki of 220 nM), and has a higher affinity to RARβ. LE135 is highly selective over RARγ, RXRα, RXRβ and RXRγ. LE135 is also a potent TRPV1 and TRPA1 receptors activator with EC50s of 2.5 μM and 20 μM, respectively.
Product Specifications
CAS Number
155877-83-1
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 50 mg/mL (114.01 mM; Ultrasonic)
Smiles
CN1c2cc3c (cc2N=C (c2ccc (cc2) C (O) =O) c2ccccc12) C (C) (C) CCC3 (C) C
Molecular Formula
C29H30N2O2
Molecular Weight
438.56
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Available Sizes
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