TAS-119
TAS-119 is a potent, selective and orally active Aurora A inhibitor with an IC50 of 1.0 nM. TAS-119 shows high selectivity for Aurora A over other protein kinases, including Aurora B (IC50 of 95 nM) . TAS-119 has potent antitumor activites.
Product Specifications
CAS Number
1453099-83-6
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 50 mg/mL (98.74 mM; Ultrasonic)
Smiles
Cc1cc (Nc2nc (CC3 (CCN (CC3) C (=O) c3cccc (Cl) c3Cl) C (O) =O) ccc2F) n[nH]1
Molecular Formula
C23H22Cl2FN5O3
Molecular Weight
506.36
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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