CUR5g
CUR5g is a potent autophagy inhibitor. CUR5g selectively inhibits autophagosome degradation in cancer cells by blocking autophagosome-lysosome fusion. CUR5g blocks the recruitment of STX17 to autophagosomes via a UVRAG-dependent mechanism, resulting in the inability of autophagosomes to fuse with lysosomes. CUR5g improves the anticancer effect of Cisplatin (HY-17394) against A549 cells both in vitro and in vivo.
Product Specifications
CAS Number
1370032-20-4
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 41.67 mg/mL (120.99 mM; Ultrasonic (<60°C)
Smiles
C (\C=1C=2C (NC1) =CC=CC2) =C\3/C (=O) \C (=C\C4=CC=C (O) C=C4) \CN (C) C3
Molecular Formula
C22H20N2O2
Molecular Weight
344.41
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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