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GSK-3 inhibitor 3

GSK-3 inhibitor 3 is a selective, orally active and brain-penetrant inhibitor of GSK-3, with IC50s of 0.35 nM and 0.25 nM for GSK-3α and GSK-3β, respectively. GSK-3 inhibitor 3 lowers levels of tau protein phosphorylation at S396 in a triple-transgenic mouse Alzheimer’s disease model, with IC50 of 10 nM. GSK-3 inhibitor 3 can be used for neurological disease research.

Product Specifications

CAS Number

2227279-84-5

Field of Research

Pharmacology & Drug Discovery

Purity

>98% (HPLC)

Solubility

In Vitro: DMSO : 50 mg/mL (121.83 mM; Ultrasonic)

Smiles

N (C (=O) C1=NC (NC2=CC=C (C#N) C=C2) =NC=C1) C=3C (=CC=NC3) C4=CC=C (F) C=C4

Molecular Formula

C23H15FN6O

Molecular Weight

410.4

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Available Sizes

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